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Compared to never smokers, the multivariable adjusted subhazard ratio for myocardial infarction was 1.09 (95%CI0.88-1.35) for former smokers with the highest methylation degree, 1.38 (1.06-1.8 for active smokers with the highest methylation extent, 1.39 (1.08-1.78) for former smokers with the lowest methylation extent, and 1.61 (1.35-1.92) for active smokers with the lowest methylation extent. AHRR cg05575921 hypomethylation as an epigenetic marker of smoking history predicts risk of myocardial infarction, particularly in former smokers. Further, AHRR hyp