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Simple and complex glomerulations were distinguished by gland size and intraluminal cribriform protrusions. Medical endpoint had been biochemical recurrence-free success. Glomerulations had been identified in 365 (34%) specimens. In 472 Grade Group 2 patients, 210 (44%) had simple and 92 (19%) complex glomerulations. Advanced glomerulations coincided with cribriform structure more regularly than simple glomerulations (67% versus 52%; P = 0.01). Men with simple glomerulations ha