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01) in the dominant model, and was stronger among postmenopausal women (OR 0.68, P = 0.03) and for ER+ cancer (OR 0.66, P = 0.001). Four SNPs (rs3840880, rs1126667, rs434473, rs1042357) in the ALOX12 gene were found in high LD (r2 0.98) in White women and were similarly associated with reduced risk of breast cancer, with a stronger association among postmenopausal women and for ER- cancer. Among Black women, increased risk was observed for ALOX5-rs1369214 (OR 1.44, P = 0.003) in the recessive model and was stronger among premenopau