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96 ± 6.33% and 80.59 ± 0.30%, respectively, was achieved.Spray drying is the most commonly used encapsulation technique to stabilize sensitive bioactive compounds and sometimes enhances their performance. Vitamin B12 and vitamin D3 deficiencies are reported worldwide and co-encapsulation can provide a combined solution to this problem. The present work aimed at encapsulation of vitamin B12 and D3 by spray drying using experimental design to optimize wall material combination. Optimized solution obtained from the experimental design (gum
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