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Dent 2020;13(4)327-331. In the anterior maxillary region when periapical (PA) surgery is contemplated, knowledge of relation between root apices and lesion, spatial relationship of tooth root to adjacent anatomical structures is essential. The aim of this study was to compare cone-beam computed tomography (CBCT) and PA radiography to determine the proximity of PA lesions to anatomical structures in the premaxillary area for decision-making before apical surgery. Twenty subjects were selected. Three endodontists viewed PA radiographs and