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The proband (diligent 1), a 60-year-old male, offered sluggish progressive gait uncertainty, serious cognitive disability, and mental condition for over two years with a history of ischemic stroke and hypertension. His more youthful cousin (Patient 2) offered apparent gait difficulties, dysarthria also cognitive decline at 59 yrs old. Brain magnetic resonance imaging (MRI) revealed diffused white matter lesions concerning bilateral periventricular white matter, semiova