https://www.selleckchem.com/pr....oducts/azd5153-6-hyd
We then investigate the role of a specific mutation directly related to ion selectivity in LGICs, the E-1' → A-1' substitution at the cytoplasmatic selectivity filter. We find that the mutation strongly affects sodium and chloride permeation in opposite directions, leading to a complete inversion of selectivity, at variance with the limited experimental results available that classify this mutant as cationic. We thus provide structural determinants for the observed cationic-to-anionic inversion, revealing a ke
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