https://www.selleckchem.com/pr....oducts/lanifibranor-
Mutations in GPR179 lead to autosomal recessive complete congenital stationary night blindness (cCSN. This condition represents a signal transmission defect from the photoreceptors to the ON-bipolar cells. To confirm the phenotype, better understand the pathogenic mechanism in vivo, and provide a model for therapeutic approaches, a Gpr179 knock-out mouse model was genetically and functionally characterized. We confirmed that the insertion of a neo/lac Z cassette in intron 1 of Gpr179 disrupts the same gene. Spectral domai
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