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The above results shed some light on a better understanding of the traditional anti-inflammation effect of M. exotica and coumarins are disclosed to be its potential anti-inflammatory constituents.A voltage-gated potassium channel encoded by the human ether-à-go-go-related gene (hERG) regulates cardiac action potential, and it is involved in cardiotoxicity with compounds that inhibit its activity. Therefore, the screening of hERG channel blockers is a mandatory step in the drug discovery process. The screening of hERG blockers by using