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d significant differences in ADC and microstructural parameters. The skewness of ρ was the parameter with highest AUC (0.9 and sensitivity (0.75). Matching measured with simulated ADC yielded a set of potential imaging markers for meningiomas grading and response monitoring in proton therapy, showing higher specificity than conventional ADC. These markers can provide discriminative information about spatial patterns of tumor microstructure implying important advantages for patient-specific proton therapy workflows. Matching measured w