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Identifying modifiable risk factors for cognitive decline can reduce burden of dementia. We examined whether homocysteine was associated with memory performance, mediated by entorhinal volume, hippocampal volume, total gray matter volume, or white matter lesions, and moderated by APOE ɛ4 allele, B vitamins, creatinine, total cholesterol, or triglycerides. All 204 members of the Czech Brain Aging Study with subjective cognitive decline (SCD; n = 6 or amnestic mild cognitive impairment (aMCI; n = 144) who had valid data were included. L