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The pooled estimates did not exhibit any significant associations between SNPs rs3814055 and rs7643645 and the risk of ATDH (rs3814055 dominant model, OR = 1.00, 95% CI 0.82-1.22, P = 1.00; recessive model, OR = 1.17, 95% CI 0.76-1.78, P = .48; rs7643645 dominant model, OR = 1.04, 95% CI 0.64-1.68, P = .89; recessive model, OR = 0.98, 95% CI 0.65-1.49, P = .93). Subgroup analysis obtained similar negative results in Chinese patients, and the diagnostic criteria of ATDH may be the source of heterogeneity. Based on the meta-analysis describ