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003) and 5-year recurrence-free survival (RFS) (p0.001). The TPA decreasing group also showed a poor 5-year OS in patients who developed severe postoperative complications (p=0.015). Multivariate analyses showed that decreased TPA was found to be independently associated with OS (p=0.017) as well as RFS (p=0.002). Our findings suggested a relationship between decreased TPA within 1week after esophagectomy and long-term prognosis among patients with esophageal cancer. If TPA can be maintained, the prognosis was better even in cases wit