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Simultaneously, TQ suppressed the pro-oncogenic JAK2/STAT3 pathway, leading to decreased expression of Bcl-2, Bcl-xl, cyclin D1, cyclin D2, and survivin. Therefore, TQ can integrate between apoptosis as well as the pro-survival JAK2/STAT3 pathway through the Bcl family unit members, collectively magnifying Caki-1 cell apoptosis. Nevertheless, therapy utilizing the ROS scavenger N-acetyl cysteine notably blocked TQ-induced apoptosis along with included signaling paths, supporting that its pro-