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58, 21.5% vs. 34.1% respectively, P = 0.001). Patients treated with plugs that did develop dry eye disease did so later (51.2 ± 77.64 days' vs. 20.78 ± 26.9 days, P = 0.009). Postoperative visual acuities were similar between groups (P 0.05) at all postoperative follow-up visits as were safety (0.95 ± 0.16 vs. 0.99 ± 0.09, P = 0.3 and efficacy (1.01 ± 0.13 vs. 1.00 ± 0.11, P = 0.52) indices. Preventative temporary punctal plug placement during LASIK appears to reduce dry eye disease in the short term, without affecting visual acui