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What Happens If is Left Untreated in Adults? Untreated ADHD can lead to a myriad of problems for adults. These include problems with relationships, work and mental health. Often, adults with untreated ADHD have low self-esteem as well as a negative perspective on the world. This can make them feel like they're failing both at work and at home. Lack of Focus It is normal to experience difficulties focusing from time to moment especially after a long day a