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The study presents a historical analysis of the problems of standardization of methods for determining ESR. The modern approaches to the automation of ESR research are presented. It is shown that the solution to the problems of standardization of methods for determining ESR lies in the plane of regular intra-laboratory quality control. In accordance with the principles of evidence-based medicine, recommendations are given on the use of methods for determining ESR in clinical practice.The content of metal ions and proteins containing or
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