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The HRCA-strip platform could achieve highly sensitive and specific miRNA 31 detection with the limit of detection (LOD) as low as 3.21 fM. Moreover, the designed HRCA-strip platform also enabled portable detection of miRNA 31 in clinical sample which might show good potential for early clinical diagnosis of OSCC.The aggregation and redispersion of positively-charged AuNPs ((+)AuNPs) modified with cysteamine (CS) could be regulated by the negatively charged As(III)-specific aptamer (As(III)-apt). In general, (+)AuNPs aggregated with inc