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The result of ACGs, with higher importance in health, would be that they provide anti-tumor task; nevertheless, the techniques of removal of ACGs are extremely sluggish along with a higher expenditure of solvents. To the understanding, there is absolutely no report of an optimal way for the removal of acetogenins from the Annonaceae family members by ultrasound-assisted extraction (UAE); consequently, desire to would be to find the best UEA circumstances