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In the gangrenous appendicitis group, expression of genes delineating antibacterial mechanisms was found. These results provide evidence for different and independent gene expression in phlegmonous and gangrenous appendicitis in general, but also suggest distinct immunological patterns for the respective entities. In particular, the findings are compatible with previous evidence of spontaneous resolution in phlegmonous and progressive disease in gangrenous appendicitis. These results provide evidence for different and independent gene e