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Then, a Swap-and-Judge Simulated Annealing (SJSA) algorithm is therefore proposed to improve the efficiency of generating feasible neighboring solutions. Extensive experimental and comparative studies on different scenarios demonstrate the efficiency of the proposed algorithm compared with the exact algorithm and meta-heuristic algorithms. The results also inspire us about the characteristics of a population-based algorithm in solving combinatorial discrete optimization problems.PF4 is a megakaryocyte-derived cationic chemokine that