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ecipients receiving organs from public health service increased risk donors.Casparian strip (CS) is a lignified structure localized on the cell wall between adjacent root endodermal cells and functions as an apoplastic diffusion barrier in the root. The polarly localized, lignin-based CS is an excellent system for studying peptide signaling and position recognition. In this short review, we summarize advances in the past decade on the molecular mechanism governing CS development. In addition to the multi-protein framework underlying the