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795, P .001; 0.757, P = .001; 0.717, P = .005, respectively). All 3 markers were correlated with the presence of carcinoid syndrome (AUROC = 0.702, P = .006; 0.701, P = .006; 0.697, P = .007, respectively), carcinoid heart disease (AUROC = 0.896; 0.887; 0.923, P .001, respectively, P .001), and liver metastatic involvement greater than 30% (AUROC = 0.827; 0.807; 0.849, P .001, respectively, P .001), independent from other traditional prognostic factors. Biomarker levels were similar between patients with optima