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However, after ketamine injection, temporal expectation was significantly reduced in both subjects. In addition, ketamine also increased average movement latency but this effect could be dissociated from the reduction of temporal expectation. In conclusion, a subanesthetic dose of ketamine could have two independent effects increasing reaction time and decreasing temporal expectation. This alteration of temporal expectation could explain cognitive deficits observed during ketamine use. In conclusion, a subanesthetic dose of ketamine cou