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This BC catalytic chemistry facilitates haze development and explains the observed trends of regional haze in China. Our results imply that reduction of SO2 alone is insufficient in mitigating haze occurrence and highlight the necessity of accurate representation of the BC chemical and radiative properties in predicting the formation and assessing the impacts of regional haze. Copyright © 2020 the Author(s). Published by PNAS.Copper-containing nitrite reductases (CuNIRs) transform nitrite to gaseous nitric oxide, which is a key process