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This study reports a new perspective for the simultaneous oxidation of a volatile organic compound (VOC) - a toluene gas stream - and a real industrial liquid effluent by the Fenton's process; for that, a lab-scale bubbling reactor, operating in semi-continuous mode, was used. A parametric study was carried out to evaluate the effect of the aqueous matrix (water vs. real effluent), catalyst species nature (Fe2+ vs. Fe3+), concentration of organic matter in the liquid, and inlet toluene concentration in the gas phase. Their effects in the