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With failure of genome-wide association study (GWAS) and other studies performed on nuclear genome to offer any clue for accurate process of PCOS pathogenesis, attention has-been redirected to mitochondria. Mitochondrion plays an important role in cellular metabolic features and it is linked to Insulin Resistance (IR). Recently, increasing reports declare that mitochondrial disorder may be a contributing element in the pathogenesis of PCOS. Ergo, in this analysis, we have talked abou