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We concluded that Nrf2 deficiency and increasing age may activate AMPK and ROS signals to cause excessive autophagy activation in skeletal muscle, which can be a potential mechanism for the development of sarcopenia.OBJECTIVE The aim of the study was to assess serum chemerin concentration and subcutaneous adipose tissue (SAT) chemerin expression in relation to insulin sensitivity and obesity in young healthy subjects. DESIGN We performed a cross-sectional study including 128 subjects, 44 normal-weight, 44 with overweight and 40 with ob