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41, P .001; monotherapy χ²₂ = 11.73, P = .003). The changes in CGI-S score were significantly different according to the duration of illness, and those with duration of illness 3 years showed the best improvement (group × week χ²₁₂ = 25.33, P = .013). All 3 groups showed significantly improved PSP scores (week χ²₆ = 294.2, P .001). Starting paliperidone LAI significantly improved clinical and functional outcomes in patients with schizophrenia, especially those with shorter duration of illness. These findings suggest that L
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