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5 (95% CI, -5.9 to -3.1) mmHg (p0.1 for all outcomes). CONCLUSIONS Empagliflozin induced a clinically relevant reduction in SBP and consistently improved all outcomes regardless of prHT status. Due to these dual effects, empagliflozin should be considered for patients with hypertension and T2D. © The Author(s) 2020. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd.The maintenance of axons for the lifetime of an organism requires an axonal cytoskeleton that is robust but also flexible to adapt to