https://www.selleckchem.com/pr....oducts/pf-07104091.h
Topoisomerase IIβ-binding protein 1 (TopBP1) is involved in cellular replication among other functions, and is known to activate ATR/Chk1 during replicative stress. TopBP1 is also expressed at high levels in many cancers. However, the impact of TopBP1 overexpression on ATR/Chk1 activation and cancer development has not been investigated. Here we demonstrate that the degree of ATR/Chk1 activation is regulated by TopBP1 in a biphasic, concentration-dependent manner in a non-transformed MCF10A cell line and several cancer cell lines, i
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