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A larger number of tumor-infiltrating CD8 Tex (88.94%) cells were found in the colon cancer than in the rectal cancer (11.06%). The T cells of the colon and rectal cancers showed changes in gene expression pattern. We characterized the T cell populations in the CRC tumor tissue and peripheral blood. We characterized the T cell populations in the CRC tumor tissue and peripheral blood.Blocking the immune evasion mechanism of tumor cells has become an attractive means for treating cancers. However, the usage of a drug such as nivolumab (αP