https://www.selleckchem.com/products/cw069.html
These results demonstrated that 16h is a potential candidate for the development of anticancer agents targeting Aurora A kinase. This study reports the synthesis of a series of 2-aroylisoindoline hydroxamic acids employing N-benzyl, long alkyl chain and acrylamide units as diverse linkers. In-vitro studies led to the identification of N-benzyl linker-bearing compound (1 and long chain linker-containing compound (17) as dual selective HDAC6/HSP90 inhibitors. Compound 17 displays potent inhibition of HDAC6 isoform (IC50 = 4.3 nM) and HSP9
Like
Comment
Share
