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There were 3821 N. gonorrhoeae strains identified from 23 countries and 684 (18%) had diminished susceptibility to ceftriaxone. Tall sensitivities or specificities (95%) were found for specific hereditary mutations in penA, penB, mtrR, and ponA, both with and without determination of penA mosaicism. Four formulas to predict ceftriaxone susceptibility had been proposed centered on penA mosaicism dedication and penA or non-penA genetic mutations, with sensitiveness