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The statistics of APOE alleles showed that APOE2 allele carriers were almost certainly going to nvAMD. VEGF, PDGF-BB, b-FGF and related inflammatory cytokines were up-regulated somewhat after therapy with APOE2, that have been reduced after silencing the MAPK household genetics, however. More, the appearance amounts of neovascular development factors and inflammatory cytokines were highly constant between mouse models and ARPE-19 cells. Besides, the phosphoryl