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0.34, total score r = 0.68; KPS and QOL-CD general health r = 0.32, total score r = 0.14). Perioperative testing of CD patients (n = 25) demonstrated improvement in all subscales postoperatively, with a significant difference in emotional health (p less then 0.001) and physical health (p less then 0.001). Conclusions The QOL-CD questionnaire has been developed for patients with CD and has demonstrated evidence for validity and reliability.Objective Innovations in genomics, epigenomics, and transcriptomics now lay the groundwork for therapeutic interventions