https://nartpathway.com/lie-di....scovery-accuracy-alo
Ageing is the best danger element for neurodegenerative conditions. Hypothesizing that age-dependent processes together with haploinsufficiency of TANK-binding kinase 1 could produce a double hit scenario that will trigger neurodegeneration, we examined mice with hemizygous deletion of Tbk1 (Tbk1+/- mice) and wild-type siblings as much as 22 months. Compared to 4-month old mice, aged, 22-month old mice showed glial activation, deposition of motoneuronal p62 aggregates, muscular denervation and serious transcriptom
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