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Members of the ADF/cofilin family of regulatory proteins bind actin filaments cooperatively, locally change actin subunit conformation and orientation, and sever filaments at 'boundaries' between bare and cofilin-occupied segments. A cluster of bound cofilin introduces two distinct classes of boundaries due to the intrinsic polarity of actin filaments, one at the 'pointed' end-side and the other at the 'barbed' end-side of the cluster; severing occurs more readily at the pointed end side of the cluster ('fast-severing' boundary) than th