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Our study reinforces the role of BM biopsy as diagnostic tool in MDSs, being also able to supply information related to response to ESAs and to its loss over time. Chronic diarrhea is defined as more than three bowel movements per day, or loose stools, or stool weight 200 g/d for at least 4 weeks. Accompanying symptoms may include urgency, abdominal pain or cramps. A number of causes have to be considered, including inflammatory, neoplastic, malabsorptive, infective, vascular and functional gastrointestinal diseases. Other causes i