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y for acute low back pain that may reduce reliance on high-risk medications while improving patient-reported outcomes. Emergency department-initiated physical therapy for low back pain was associated with greater improvement in functioning and lower use of high-risk medications over 3months. Emergency department-initiated physical therapy for low back pain was associated with greater improvement in functioning and lower use of high-risk medications over 3 months. Studies have indicated that homocysteine levels are nontraditional markers