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High sensitivity towards Cu toxicity is problematic when using some hyperaccumulator plants for phytoremediation of soils with mixed contamination of Cu. Sedum alfredii, a Cd/Zn co-hyperaccumulator and Pb accumulator, is trusted for remediation of Cd, Zn, and Pb co-contaminated grounds in Asia. In this paper, the threshold and buildup capability of S. alfredii towards Cu anxiety as well as its potential for phytoremediation of multi-metal polluted grounds ha