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Of the patients with RA, 10.1% were still difficult to treat in the real world despite intensive treatment. Their characteristics were distinct by the reasons of D2T RA, which suggests the need for a personalised approach to D2T RA. Of the patients with RA, 10.1% were still difficult to treat in the real world despite intensive treatment. Their characteristics were distinct by the reasons of D2T RA, which suggests the need for a personalised approach to D2T RA.Interferon (IFN) plays a role in immune and inflammation responses. However, t
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