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First Line Treatment For ADHD in Adults Some people with ADHD are able to use medications to manage their symptoms. The stimulants like methylphenidate or amphetamine help by enhancing brain activity in areas that regulate attention and behavior. Other medications, such as the nonstimulant atomoxetine and some antidepressants, perform differently but are also efficient. Patients who are taking medication should visit their GP regularly to monitor bodily reactions and alter dosages. Medication Adults