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ADHD Treatment Medication Adults with ADHD are typically treated with medication and psychosocial therapy. The medications used to treat ADHD include stimulants as well as non-stimulant medication. Stimulants like methylphenidate and Lisdexamfetamine work on brain chemical messengers to improve concentration, mood and control of impulses. Atomoxetine and guanfacine are nonstimulant ADHD medicines that may be given to teenagers, adults or children if they do not respond to stimulants