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We set out to investigate the effectiveness of naloxone against a potentially lethal dose of inhaled carfentanil in male ferrets. Ferrets were implanted with telemetry devices to examine cardiac variables and subjected to aerosolized carfentanil in a whole-body plethysmography chamber to record respiratory variables. We noticed powerful breathing depression in uncovered creatures, which generated apneic periods constituting 24-31 % of the exposure duration. Concomitant with these