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We propose that in Si- roots, the modified lignin crosslinked into the cell wall and lost its ability to nucleate silica. In Si+ roots, silica polymerized on the modified lignin and altered its structure. Our work demonstrates a profound control over lignin and silica deposition in cell walls. © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email [email protected] hypothalamus is a key homeostatic brain region and the