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The current results suggested that TM inhibited mobile viability and presented apoptosis in person major epidermal melanocytes. Western blot analysis shown that the expression of Bax and caspase-3 had been upregulated together with expression of Bcl-2 had been downregulated in TM-treated real human melanocytes. The consequences of TM on man melanocytes were corrected by RIPK1 overexpression. Consequently, RIPK1 overexpression may have an effect on the PI3K/AKT/mTOR sig