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For the 91-min scan duration, the influx constant K1 increased by 40.7per cent in addition to number of distribution (VT) by 30.4% after P-gp inhibition, even though the efflux continual k2 did not alter considerably. Similar modifications were found for several evaluated scan durations. K1 didn't be determined by scan extent (10 min-K1 = 0.2191 vs 91 min-K1 = 0.2258), while VT and k2 did. A scan period of 10 min seems enough to properly measure the P