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This finding contrasts the gender differences in common neurodegenerative diseases. We propose that additional sex-dependent co-morbidities, such as chronic stress, protein misfolding, traumatic brain injury or other pathological mechanisms may explain the increased risk for developing proteinopathies rather than pre-existing suppression of glymphatic influx.The early evidence of domesticated animals and human-animal interaction in South Asia can be traced back to the seventh millennium BCE; however, our understanding of their use is in