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Skin neoplasms are the most frequent malignant lesions, increasing patient's morbidity when associated with skin field cancerisation. There is a need to understand the current therapies, both clinical and surgical. A systematic review was performed according to the PRISMA guideline, registered in PROSPERO CRD42018114826, including studies from 2012 to 2019. Seven hundred and eighty-two studies were found, of which 21 were included. Of these, 8 primary studies were randomised controlled trials fractional CO laser-assisted photodynamic the